Description
Humanin 10 mg — Mitochondrial-Derived Peptide for Cell-Survival & Aging Research
Humanin is a small mitochondrial-derived peptide (MDP) originally
identified in relation to neuronal survival under toxic and stress conditions. In preclinical
and translational research, Humanin and related MDPs have been studied for roles in
cell-protective signaling, metabolic stress responses, and healthy-aging biology.
What It Is
- Class: Mitochondrial-derived peptide (MDP)
- Origin concept: Encoded by a small open reading frame associated with
mitochondrial DNA; peptide detected in multiple tissues and circulation in research settings. - Research focus: Cell survival, stress resistance, neuroprotection,
and age-related metabolic and vascular changes.
Proposed Mechanisms (Preclinical)
Cell-Survival & Stress Pathways
- Investigated for protection against oxidative, metabolic, and apoptotic
stressors in neuronal and non-neuronal models. - Explored for modulation of apoptosis-related signaling (pro- and
anti-apoptotic proteins, mitochondrial integrity). - Experimental data suggest interactions with pro-survival receptors and
cytokine-like signaling in select systems.
Aging, Metabolism & Mitochondria
- Part of broader research into mitochondria-to-nucleus signaling
and peptide-based regulators of aging. - Preclinical models examine effects on insulin sensitivity, vascular function,
and cognitive performance under aging or stress conditions. - Interest in Humanin as a circulating peptide biomarker associated
with longevity-related phenotypes in some cohorts.
Selected Research Highlights
- Neuroprotection: Humanin has been studied in neuronal and
neurodegeneration models for effects on cell survival, synaptic integrity,
and cognitive endpoints. - Metabolic & Vascular Models: Experimental work includes impacts
on insulin signaling, endothelial function, and oxidative stress
in metabolic-syndrome and vascular-aging models. - Aging & Longevity Research: MDPs such as Humanin are being investigated
as mediators of healthy aging, stress resilience, and mitochondrial communication.
Chemical & Handling Information
- Type: Synthetic mitochondrial-derived peptide analog
- Peptide length: Short peptide (exact sequence/length per specification/lot)
- Appearance: White to off-white lyophilized powder
Specifications
- Peptide: Humanin
- Amount: 10 mg per vial
- Form: Lyophilized powder
- Purity: ?99% (HPLC); COA per lot available
- Packaging: Sealed vials suitable for standard laboratory handling
Storage & Stability
- Store lyophilized vials in a cool, dry place, protected from light.
- Refrigeration or freezing of the lyophilized peptide is recommended for extended stability,
according to laboratory SOPs. - After reconstitution, store at 2–8 °C for short-term use.
- For long-term storage, aliquot and freeze at ?20 °C or below; avoid repeated freeze–thaw cycles.
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