Description
Mazdutide 10 mg — Dual GLP-1/Glucagon Receptor Agonist for Metabolic Research
Mazdutide is an investigational dual receptor agonist designed to
activate both the GLP-1 (glucagon-like peptide-1) receptor and the
glucagon receptor (GCGR). In preclinical and clinical research, dual
GLP-1/GCGR agonists have been studied for their effects on body weight, glycemic
control, liver fat, and overall energy metabolism in obesity and related metabolic
disease models.
What It Is
- Class: Dual GLP-1/GCGR peptide agonist
- Concept: Combines GLP-1–mediated appetite and glucose control
with glucagon-receptor–mediated effects on energy expenditure and lipid handling. - Format: Research-grade synthetic peptide supplied as a lyophilized powder.
Proposed Mechanisms (Preclinical)
GLP-1 Pathways
- Activates GLP-1 receptors to enhance
glucose-dependent insulin secretion in experimental models. - Investigated for reductions in inappropriate glucagon secretion
during hyperglycemia. - Modulates gastric emptying and appetite/satiety signaling in
central nervous system pathways.
Glucagon & Energy Expenditure
- Engages glucagon receptors in liver and other tissues, with
research focus on energy expenditure, lipid mobilization, and liver fat. - Dual activation is studied for shifting substrate use toward fat oxidation
under obesogenic conditions. - Model-dependent changes in body composition, hepatic markers, and metabolic rate
are active areas of investigation.
Selected Research Highlights
- Obesity & Weight Models: Dual GLP-1/GCGR agonists such as Mazdutide
have been examined for body-weight reduction, fat-mass changes, and waist
measures in obesity research. - Glycemic Control: Studies include effects on fasting glucose, post-prandial
responses, and longer-term glycemic markers in metabolic-disease cohorts. - Liver & NAFLD/NASH: A key interest is the impact on hepatic
steatosis, liver fat content, and liver-enzyme profiles. - Cardiometabolic Markers: Ongoing research explores blood pressure, lipids,
inflammatory indices, and other cardiovascular risk parameters under dual-agonist exposure.
Chemical & Handling Information
- Type: Synthetic dual GLP-1/glucagon receptor agonist
- Targets: GLP-1 receptor and glucagon receptor (GCGR)
- Appearance: White to off-white lyophilized powder
Specifications
- Peptide: Mazdutide
- Amount: 10 mg per vial
- Form: Lyophilized powder
- Purity: ?99% (HPLC); COA per lot available
- Packaging: Sealed vials suitable for standard laboratory handling
Storage & Stability
- Store lyophilized vials in a cool, dry place, protected from light.
- Refrigeration or freezing of the lyophilized peptide is recommended for extended stability,
according to laboratory SOPs. - After reconstitution, store at 2–8 °C for short-term use.
- For long-term storage, aliquot and freeze at ?20 °C or below; avoid repeated freeze–thaw cycles.
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