Description
NAD+ 50 mg — Oxidized Nicotinamide Adenine Dinucleotide for Cellular-Energy Research
NAD+ (nicotinamide adenine dinucleotide, oxidized form) is a central
pyridine nucleotide cofactor involved in cellular redox reactions, energy metabolism,
and signaling. In preclinical and human research, NAD+ and related precursors
have been investigated for roles in mitochondrial function, sirtuin activity, and responses
to metabolic and oxidative stress.
What It Is
- Class: Oxidized pyridine nucleotide coenzyme
- Core roles: Electron carrier in glycolysis, the tricarboxylic-acid (TCA)
cycle, and oxidative phosphorylation; substrate for several signaling enzymes. - Research focus: Cellular energy balance, mitochondrial biology, redox state,
and NAD+-dependent signaling pathways.
Proposed Mechanisms & Pathways (Preclinical)
Redox & Energy Metabolism
- Central to NAD+/NADH redox cycling in energy-producing
pathways (glycolysis, TCA cycle, electron transport chain). - Influences ATP generation and mitochondrial respiratory-chain activity
in cell and animal models. - Changes in NAD+ pools are associated with shifts in metabolic flexibility and
substrate utilization in research settings.
Signaling & Stress Responses
- Acts as a substrate for sirtuins (SIRT family), PARPs, and other
NAD+-consuming enzymes involved in DNA repair, chromatin structure, and
stress responses. - Explored in models of oxidative stress, inflammation, and cellular aging
where NAD+ availability may modulate key signaling pathways. - Part of broader research into NAD+ metabolism and salvage pathways
(e.g., NAMPT, NMN/Niacin derivatives).
Selected Research Highlights
- Mitochondrial Function: NAD+ levels and NAD+/NADH ratios
are widely used readouts in studies of mitochondrial performance, bioenergetics, and
respiratory-chain function. - Aging & Cellular Stress: Experimental work has linked altered
NAD+ metabolism to markers of cellular aging, DNA damage responses, and
stress resistance in multiple model systems. - Metabolic Models: NAD+-related interventions are used to
probe glucose and lipid metabolism, insulin sensitivity, and metabolic health markers
in preclinical and early clinical research. - Sirtuin & PARP Research: NAD+ serves as a required substrate
in studies of sirtuin-mediated deacetylation and PARP-mediated poly(ADP-ribosyl)ation,
with downstream effects on gene expression and repair pathways.
Chemical & Handling Information
- Type: Nicotinamide adenine dinucleotide, oxidized form (NAD+)
- Class: Pyridine nucleotide cofactor
- Appearance: White to off-white lyophilized powder (hygroscopic; handle promptly)
Specifications
- Compound: NAD+ (nicotinamide adenine dinucleotide, oxidized form)
- Amount: 500 mg per vial
- Form: Lyophilized powder
- Purity: ?99% (HPLC); COA per lot available
- Packaging: Sealed vials suitable for standard laboratory handling
Storage & Stability
- Store lyophilized vials in a cool, dry place, protected from light and moisture.
- Refrigeration or freezing of the lyophilized material is recommended for extended stability,
according to laboratory SOPs. - After reconstitution, store at 2–8 °C for short-term use.
- For longer-term storage, aliquot and freeze at ?20 °C or below; avoid repeated freeze–thaw cycles.
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