Description
Semax 5 mg — Heptapeptide Analog for Neuropeptide & Cognitive Research
Semax is a synthetic heptapeptide analog derived from the
adrenocorticotropic hormone (ACTH) fragment ACTH(4–10), with additional modifications
to enhance stability. In preclinical and clinical research, Semax has been investigated
for its effects on cerebral blood flow, neurotrophic-factor expression, cognitive
performance, and neuroprotection under stress or ischemic conditions.
What It Is
- Class: ACTH-derived neuropeptide analog
- Peptide length: 7 amino acids (heptapeptide)
- Research focus: Cognitive function, attention, learning/memory,
and brain stress-response models.
Proposed Mechanisms (Preclinical)
Neurotrophic & Synaptic Effects
- Investigated for upregulation of BDNF and other neurotrophic factors
in brain tissue models. - Explored for modulation of synaptic plasticity, learning, and memory
markers in animal studies. - Model-dependent impacts on gene-expression profiles linked to
neuronal survival and adaptation.
Neuroprotection & Stress Response
- Used in ischemia/hypoxia and oxidative-stress models to study
potential neuroprotective signaling. - Evaluated for effects on cerebral blood flow, antioxidant defenses,
and inflammatory mediators. - Research interest in cognitive performance under stress, fatigue,
or high cognitive load conditions.
Selected Research Highlights
- Cognitive & Attention Models: Semax has been studied in tasks
assessing attention, learning, and memory as experimental endpoints. - Ischemic Brain Models: Experimental work includes models of
cerebral ischemia/hypoxia with readouts such as infarct size,
functional recovery, and neuronal survival markers. - Stress & Adaptation: Investigations examine behavioral and
biochemical responses to acute and chronic stressors, with a focus
on adaptation and resilience markers.
Chemical & Handling Information
- Type: Synthetic ACTH-derived heptapeptide analog
- Peptide length: 7 amino acids
- Appearance: White to off-white lyophilized powder
Specifications
- Peptide: Semax
- Amount: 5 mg per vial
- Form: Lyophilized powder
- Purity: ≥99% (HPLC); COA per lot available
- Packaging: Sealed vials suitable for standard laboratory handling
Storage & Stability
- Store lyophilized vials in a cool, dry place, protected from light.
- Refrigeration or freezing of the lyophilized peptide is recommended for extended stability,
according to laboratory SOPs. - After reconstitution, store at 2–8 °C for short-term use.
- For long-term storage, aliquot and freeze at −20 °C or below; avoid repeated freeze–thaw cycles.
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