Description
SNAP-8 10 mg — Acetyl Octapeptide-3 for Neuromodulatory & Cosmetic Peptide Research
SNAP-8 (Acetyl Octapeptide-3) is a synthetic octapeptide described as a
neuromodulating peptide that mimics the N-terminal end of SNAP-25, a key protein
involved in the SNARE complex required for synaptic vesicle fusion.
In cosmetic and preclinical research, SNAP-8 has been investigated as a topical peptide
targeting expression-line and wrinkle-related endpoints.
What It Is
- Class: Synthetic octapeptide (Acetyl Octapeptide-3)
- Concept: Designed as an extended analog of Argireline®-type peptides
to interact with SNARE-complex–related pathways. - Research focus: Neuromodulatory effects at the level of vesicle
fusion/exocytosis and cosmetic skin-appearance endpoints.
Proposed Mechanisms (Preclinical/Ex Vivo)
SNARE Complex Interaction
- Modeled on the N-terminal region of SNAP-25, a component of the
SNARE complex involved in synaptic vesicle fusion. - In vitro and ex vivo cosmetic research explores interference with
neurotransmitter release at the neuromuscular junction. - Conceptually aimed at reducing repetitive expression-related muscle
contraction in superficial facial regions.
Cosmetic & Skin-Related Endpoints
- Frequently evaluated in topical formulations for visible changes
in the appearance of fine lines and wrinkles. - Studies focus on periorbital and forehead regions as common expression-line areas.
- Research interest in combining SNAP-8 with other cosmetic peptides, humectants,
and barrier-support actives.
Selected Research/Use Context
- In Vitro & Ex Vivo Models: Tested on cell and skin models for effects
on neurotransmitter release, muscle-contraction surrogates, and surface appearance. - Cosmetic Formulation Research: Widely used as a reference peptide in
the development of anti-wrinkle and “expression-line” cosmetic products.
Chemical & Handling Information
- Type: Synthetic octapeptide (Acetyl Octapeptide-3)
- Peptide length: 8 amino acids
- Appearance: White to off-white lyophilized powder
Specifications
- Peptide: SNAP-8 (Acetyl Octapeptide-3)
- Amount: 10 mg per vial
- Form: Lyophilized powder
- Purity: ?99% (HPLC); COA per lot available
- Packaging: Sealed vials suitable for standard laboratory handling
Storage & Stability
- Store lyophilized vials in a cool, dry place, protected from light.
- Refrigeration or freezing of the lyophilized peptide is recommended for extended stability,
according to laboratory SOPs. - After reconstitution, store at 2–8 °C for short-term use.
- For long-term storage, aliquot and freeze at ?20 °C or below; avoid repeated freeze–thaw cycles.
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