Description
Epitalon 10 mg — Pineal Tetrapeptide Analog for Research
Epitalon (also commonly written as Epitalon) is a synthetic tetrapeptide
analog of a naturally occurring pineal peptide complex. In preclinical and exploratory clinical
research, Epitalon is used to study pathways related to cellular aging, telomere maintenance,
circadian regulation, and oxidative-stress responses.
What It Is
- Class: Pineal gland–derived regulatory peptide analog
- Sequence: Ala–Glu–Asp–Gly (AEDG) tetrapeptide
- Origin concept: Based on peptide fractions isolated from bovine pineal
extracts (e.g., “epithalamin”) and then synthesized as a defined, research-grade molecule.
Proposed Mechanisms (Preclinical)
Cellular & Genomic Signaling
- Explored for modulation of telomerase activity and support of telomere-length
maintenance in select cell-culture models. - Investigated for effects on gene-expression patterns related to stress responses,
antioxidant defenses, and apoptosis regulation. - Model-dependent influences on markers of cellular senescence and proliferation.
Systemic & Physiologic Axes
- Studied for interaction with pineal–melatonin–circadian signaling pathways.
- Exploratory data on endocrine and immune parameters in aging animal models.
- Research interest in oxidative-stress balance and tissue-repair markers under chronic load.
Selected Research Highlights
- Telomere & Aging Models: Epitalon and related pineal peptides have been examined
for effects on telomerase activity and telomere dynamics in vitro and in aging animal models. - Circadian & Sleep Parameters: Pilot investigations report changes in melatonin
profiles and sleep–wake architecture, consistent with the peptide’s pineal origin concept. - Immune & Oxidative Stress: Experimental work has evaluated antioxidant status,
inflammatory markers, and immune indices after peptide exposure. - Dermatologic & Tissue Health: Limited exploratory studies have looked at skin
elasticity, morphologic changes, and general tissue-integrity markers in aging cohorts.
Chemical & Handling Information
- Type: Synthetic tetrapeptide (AEDG)
- Peptide length: 4 amino acids
- Appearance: White to off-white lyophilized powder
Specifications
- Peptide: Epitalon
- Amount: 10 mg per vial
- Form: Lyophilized powder
- Purity: ?99% (HPLC); COA per lot available
- Packaging: Sealed vials suitable for standard laboratory handling
Storage & Stability
- Store lyophilized vials in a cool, dry place, protected from light.
- For extended stability, refrigeration or freezing in the lyophilized state is recommended per laboratory SOPs.
- After reconstitution, store at 2–8 °C for short-term use.
- For long-term storage, aliquot and freeze at ?20 °C or below; avoid repeated freeze–thaw cycles.
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