Description
MK-677 (Ibutamoren) 50 mg — Oral GH Secretagogue & Ghrelin-Receptor Agonist for Research
MK-677 (Ibutamoren) is a non-peptide small-molecule
growth hormone secretagogue that acts as an agonist at the
ghrelin (GHS-R1a) receptor. In preclinical and human research, MK-677 has been
investigated for its ability to increase endogenous growth hormone (GH) and IGF-1
levels and for exploratory effects on body composition, sleep, and metabolic markers.
What It Is
- Class: Non-peptide GH secretagogue / ghrelin-receptor agonist
- Target: Growth hormone secretagogue receptor (GHS-R1a), related to endogenous ghrelin
- Research focus: GH/IGF-1 axis, body composition, appetite, and metabolic endpoints
Proposed Mechanisms (Preclinical)
Ghrelin Receptor & GH/IGF-1 Axis
- Acts as an agonist at GHS-R1a, mimicking ghrelin at pituitary and hypothalamic sites.
- Stimulates pulsatile GH release in experimental models and human studies.
- Leads to secondary increases in IGF-1 and related downstream anabolic markers.
Appetite, Body Composition & Metabolism
- Associated with increased appetite and caloric intake in many research settings.
- Explored for effects on lean mass, fat mass, and functional outcomes in selected cohorts.
- Model-dependent changes in glucose handling, lipids, and bone-turnover markers have been reported.
Selected Research Highlights
- GH/IGF-1 Enhancement: MK-677 has been studied for sustained elevations
of GH and IGF-1 with oral administration in both animal and human trials. - Body-Composition Research: Experimental work has examined
lean mass, fat mass, and muscle function as exploratory endpoints. - Sleep & Neuroendocrine Effects: Some studies report changes in
sleep architecture and neuroendocrine parameters, consistent with ghrelin-pathway engagement. - Aging & Catabolic States: Investigated in models of aging, immobilization,
or catabolic stress for potential impacts on GH-axis and body-composition markers.
Chemical & Handling Information
- Type: Non-peptide small-molecule ghrelin-receptor agonist
- Form: Lyophilized powder for laboratory reconstitution
- Appearance: White to off-white powder
Specifications
- Compound: MK-677 (Ibutamoren)
- Amount: 50 mg per vial
- Form: Lyophilized powder
- Purity: ?99% (HPLC); COA per lot available
- Packaging: Sealed vials suitable for standard laboratory handling
Storage & Stability
- Store lyophilized vials in a cool, dry place, protected from light and moisture.
- Refrigeration or freezing of the lyophilized compound is recommended for extended stability,
according to laboratory SOPs. - After reconstitution, store at 2–8 °C for short-term use.
- For long-term storage, aliquot and freeze at ?20 °C or below; avoid repeated freeze–thaw cycles.
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