Description
LL-37 5 mg — Human Cathelicidin-Derived Antimicrobial Peptide for Innate-Immunity Research
LL-37 is a 37–amino-acid cationic peptide derived from the human
cathelicidin precursor hCAP-18. It is a key component of the innate immune
system and has been studied extensively for its antimicrobial, immunomodulatory,
and wound-healing–related properties in preclinical models.
What It Is
- Class: Human cathelicidin-derived antimicrobial peptide
- Peptide length: 37 amino acids (C-terminal fragment of hCAP-18)
- Research focus: Host defense, epithelial barrier biology, biofilm models,
and inflammation/repair interfaces.
Proposed Mechanisms (Preclinical)
Antimicrobial & Biofilm Activity
- Exhibits broad-spectrum antimicrobial activity against bacteria,
some fungi, and enveloped viruses in vitro. - Disrupts microbial membranes via cationic, amphipathic interactions
with lipid bilayers. - Investigated in biofilm models for effects on formation,
disruption, and microbial viability.
Immunomodulation & Tissue Repair
- Modulates cytokine and chemokine production in immune and epithelial cells.
- Studied for recruitment and activation of neutrophils, monocytes,
and other innate immune cells. - Explored in wound-healing and epithelial-repair models for
effects on re-epithelialization, angiogenesis, and matrix remodeling.
Selected Research Highlights
- Skin & Wound Models: LL-37 has been evaluated in cutaneous and
mucosal injury models for combined antimicrobial and pro-repair effects. - Barrier Tissues: Used in respiratory, gut, and urothelial systems to
study epithelial defense, permeability, and inflammatory signaling. - Host-Pathogen Interaction: Experimental work examines the balance between
microbial killing, immune activation, and potential tissue irritation at higher exposures.
Chemical & Handling Information
- Type: Synthetic human LL-37 peptide
- Peptide length: 37 amino acids
- Appearance: White to off-white lyophilized powder
Specifications
- Peptide: LL-37
- Amount: 5 mg per vial
- Form: Lyophilized powder
- Purity: ?99% (HPLC); COA per lot available
- Packaging: Sealed vials suitable for standard laboratory handling
Storage & Stability
- Store lyophilized vials in a cool, dry place, protected from light.
- Refrigeration or freezing of the lyophilized peptide is recommended for extended stability,
according to laboratory SOPs. - After reconstitution, store at 2–8 °C for short-term use.
- For long-term storage, aliquot and freeze at ?20 °C or below; avoid repeated freeze–thaw cycles.
Reviews
There are no reviews yet.