Description
BPC-157 & TB-500 — Research Peptide Blend
BPC-157 (Pentadecapeptide BPC-157) 10mg and TB-500 10mg (synthetic thymosin beta-4 analog)
are laboratory peptides explored separately in preclinical models for roles in tissue protection and repair.
Together, they are often studied as a complementary blend: BPC-157 for endothelial/angiogenic and
matrix-oriented signaling; TB-500 for cytoskeletal dynamics, cell migration, and wound remodeling.
What They Are
- BPC-157: 15-amino-acid pentadecapeptide studied for effects on endothelial integrity,
angiogenic signaling, nitric-oxide–linked pathways, and collagen matrix organization. - TB-500: 43-amino-acid analog of thymosin ?4, examined for actin binding/sequestration,
cell motility, microtubule/cytoskeleton remodeling, and re-epithelialization in injury models.
Proposed Mechanisms (Preclinical)
BPC-157
- Endothelial protection & pro-angiogenic signaling (NO-linked pathways; early-growth-response factors).
- Matrix/collagen support and fibroblast migration in tendon/ligament models.
- Inflammation modulation and potential neuroprotective signaling (model-dependent).
TB-500
- Actin-binding motif
LKKTETQassociated with cytoskeletal reorganization and cell motility. - Wound-healing biology: re-epithelialization, angiogenesis, granulation-tissue quality (model-dependent).
- Inflammation-pathway modulation (e.g., miR-146a/IRAK1/TRAF6 axis, exploratory).
Selected Research Highlights
- Skin/Wound Models: TB-500 (T?4) associated with faster re-epithelialization and contraction vs. controls in animal studies; small clinical datasets in chronic wounds have explored dose-response over multi-week protocols.
- Tendon/Ligament: TB-family peptides reported more organized collagen and improved mechanical properties post-injury; BPC-157 associated with fibroblast migration and collagen deposition in tendon explants.
- Muscle: BPC-157 explored in steroid-injury muscle models for functional restoration; TB-family peptides investigated for cytoskeletal remodeling and angiogenesis in cardiac ischemia models.
- Angiogenesis & Matrix: Both peptides studied for capillary density/neo-vessel formation and ECM organization under injury stressors.
Chemical Information
- BPC-157 — Formula: C62H98N16O22 · MW: 1419.5 g/mol
- TB-500 — Formula: C212H350N56O78S · MW: 4963 g/mol
Specifications
- Form: Lyophilized powders (research-grade)
- Purity: ?99% (HPLC); COA per lot available
- Packaging: Sealed vials suitable for laboratory handling
Storage & Handling
- Store lyophilized vials in a cool, dry place, protected from light.
- After reconstitution: refrigerate at 2–8 °C.
- For long-term stability: store at ?20 °C; avoid repeated freeze–thaw cycles.
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