Description
5-Amino-1MQ 50 mg — NNMT-Pathway Small-Molecule Analog for Metabolic Research
5-Amino-1MQ is a small-molecule analog studied for its effects on the
nicotinamide N-methyltransferase (NNMT) pathway, cellular energy balance,
and adiposity-related endpoints in preclinical models. NNMT is an enzyme involved in
nicotinamide metabolism, methyl-group utilization, and NAD+ salvage
pathways, making it a target of interest in metabolic and obesity research.
What It Is
- Class: Experimental small-molecule NNMT-pathway analog
- Primary pathway: Nicotinamide N-methyltransferase (NNMT) and related
methylation/NAD+-linked biochemistry in research models - Research focus: Adiposity, energy expenditure, and metabolic-stress
responses in cell and animal studies
Proposed Mechanisms (Preclinical)
NNMT & NAD+-Related Metabolism
- Investigated for modulation of NNMT activity and downstream
nicotinamide utilization in experimental systems. - Explored for effects on methylation balance and metabolites
connected to NAD+ salvage pathways. - Model-dependent changes in markers of cellular energy status and
oxidative-stress responses.
Adiposity & Metabolic Endpoints
- Preclinical studies have examined fat-mass, adipocyte size, and adipose
gene expression under NNMT-pathway modulation. - Interest in potential shifts toward increased energy expenditure
and altered substrate use in diet-induced obesity models. - Experimental work includes readouts such as body weight, glucose handling, lipid
profiles, and inflammatory markers.
Selected Research Highlights
- Obesity Models: 5-Amino-1MQ and related compounds have been studied
in high-fat–diet and obesity models for changes in body weight, fat mass, and adipocyte
morphology. - NAD+ & Energy Biology: NNMT-targeted research explores
links between NAD+ metabolism, methylation balance, and cellular energy
homeostasis. - Inflammation & Oxidative Stress: Experimental data evaluate
inflammatory mediators and oxidative-stress markers in metabolic-stress settings.
Chemical & Handling Information
- Type: Small-molecule NNMT-pathway analog
- Form: Lyophilized powder for laboratory reconstitution
- Appearance: White to off-white powder (color may vary slightly by lot)
Specifications
- Compound: 5-Amino-1MQ
- Amount: 50 mg per vial
- Form: Lyophilized powder
- Purity: ?99% (HPLC); COA per lot available
- Packaging: Sealed vials suitable for standard laboratory handling
Storage & Stability
- Store lyophilized vials in a cool, dry place, protected from light and moisture.
- Refrigeration or freezing of the lyophilized compound is recommended for extended stability,
in accordance with laboratory SOPs. - After reconstitution, store at 2–8 °C for short-term use.
- For long-term storage, aliquot and freeze at ?20 °C or below; avoid repeated freeze–thaw cycles.
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