Description
FOXO4-DRI 5 mg — Cell-Senescence–Targeting Peptide for Aging & Stress-Response Research
FOXO4-DRI is a synthetic peptide designed to interfere with
FOXO4–p53 interactions in experimental models of cellular senescence.
In preclinical research, FOXO4-DRI has been investigated as a senescence-targeting tool
for studying cellular aging, stress responses, and tissue homeostasis.
What It Is
- Class: Synthetic FOXO4-interacting peptide analog
- Concept: Modeled to disrupt binding between the transcription factor
FOXO4 and p53 in senescent cells, promoting p53 relocalization in
experimental systems. - Research focus: Cellular senescence, stress-induced aging models,
and senescence-associated secretory phenotype (SASP) biology.
Proposed Mechanisms (Preclinical)
FOXO4–p53 Axis in Senescent Cells
- Based on work showing FOXO4 association with p53 in
senescent cells. - FOXO4-DRI is designed to disrupt FOXO4–p53 interaction, altering
p53 localization and signaling in experimental models. - Used to probe senescent-cell vulnerability and mechanisms by
which senescent cells are maintained or cleared.
Senescence, SASP & Tissue Homeostasis
- Applied in cell and animal models to study senescence-associated
secretory phenotype (SASP) and its impact on neighboring cells. - Interest in how modulation of senescent-cell burden affects tissue
repair, fibrosis, and age-related functional decline in research settings. - Part of broader senolytic/senomorphic research into aging, longevity,
and chronic stress responses.
Selected Research Highlights
- Cellular Senescence Models: FOXO4-DRI has been studied in
stress-induced senescent cell systems to examine changes in survival,
p53 localization, and SASP markers. - Aging & Tissue-Function Studies: Experimental work in animal
models has explored relationships between senescent-cell modulation
and organ function, frailty markers, and recovery from stressors. - Mechanistic Aging Research: Used as a tool compound in investigations
of cellular aging pathways, DNA-damage responses, and pro-survival signaling
in senescent vs. non-senescent cells.
Chemical & Handling Information
- Type: Synthetic FOXO4-interacting peptide analog
- Peptide length: Short peptide (exact sequence per specification/lot)
- Appearance: White to off-white lyophilized powder
Specifications
- Peptide: FOXO4-DRI
- Amount: 5 mg per vial
- Form: Lyophilized powder
- Purity: ?99% (HPLC); COA per lot available
- Packaging: Sealed vials suitable for standard laboratory handling
Storage & Stability
- Store lyophilized vials in a cool, dry place, protected from light.
- Refrigeration or freezing of the lyophilized peptide is recommended for extended stability,
according to laboratory SOPs. - After reconstitution, store at 2–8 °C for short-term use.
- For long-term storage, aliquot and freeze at ?20 °C or below; avoid repeated freeze–thaw cycles.
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