Description
PT-141 (Bremelanotide) 10 mg — Melanocortin Receptor Peptide for Sexual Function & CNS Research
PT-141 (Bremelanotide) is a synthetic melanocortin receptor peptide
derived from the ?-MSH (alpha–melanocyte-stimulating hormone) family. In preclinical and
clinical research, PT-141 has been investigated for its effects on central nervous
system pathways involved in sexual arousal, mood, and autonomic regulation.
What It Is
- Class: Melanocortin receptor agonist peptide
- Origin concept: Derived from ?-MSH–related sequences with modifications
to enhance stability and receptor activity. - Research focus: CNS melanocortin signaling, sexual function models,
and autonomic/neuroendocrine endpoints.
Proposed Mechanisms (Preclinical)
Melanocortin Receptors in the CNS
- Acts primarily at melanocortin receptors (e.g., MC3R/MC4R) in
brain regions involved in sexual arousal and autonomic output. - Investigated for CNS-mediated effects rather than peripheral sex-hormone modulation.
- Research explores downstream neuronal activation patterns, sympathetic
tone, and hemodynamic responses.
Sexual Function & Behavioral Models
- Used in animal and human studies of sexual desire, arousal, and response
under various conditions. - Model-dependent evaluation of libido, latency, and frequency endpoints.
- Interest in interactions with mood, stress, and autonomic regulation
in CNS pathways.
Selected Research Highlights
- Sexual Function Research: PT-141 has been studied for its ability to
modulate central arousal circuits in both male and female sexual-function
models. - CNS & Autonomic Effects: Experimental work examines changes in
blood pressure, heart rate, and autonomic markers alongside behavioral
endpoints. - Melanocortin Biology: Serves as a tool compound to probe
melanocortin receptor networks implicated in appetite, mood, and
autonomic regulation.
Chemical & Handling Information
- Type: Synthetic melanocortin receptor agonist peptide
- Peptide length: Cyclic peptide (exact sequence per specification/lot)
- Appearance: White to off-white lyophilized powder
Specifications
- Peptide: PT-141 (Bremelanotide)
- Amount: 10 mg per vial
- Form: Lyophilized powder
- Purity: ?99% (HPLC); COA per lot available
- Packaging: Sealed vials suitable for standard laboratory handling
Storage & Stability
- Store lyophilized vials in a cool, dry place, protected from light.
- Refrigeration or freezing of the lyophilized peptide is recommended for extended stability,
according to laboratory SOPs. - After reconstitution, store at 2–8 °C for short-term use.
- For long-term storage, aliquot and freeze at ?20 °C or below; avoid repeated freeze–thaw cycles.
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