Description
Melanotan II 10 mg — Melanocortin Receptor Peptide for Pigmentation & CNS Research
Melanotan II is a synthetic melanocortin receptor agonist peptide
derived from the ?-melanocyte–stimulating hormone (?-MSH) family. In preclinical and
exploratory human research, Melanotan II has been investigated for its effects on
skin pigmentation pathways and central melanocortin signaling
related to appetite, mood, and autonomic function.
What It Is
- Class: Melanocortin receptor agonist peptide
- Origin concept: Analog of ?-MSH with sequence modifications to
enhance stability and receptor affinity. - Research focus: Pigmentation biology, melanocortin systems in the
CNS, and autonomic/neuroendocrine readouts.
Proposed Mechanisms (Preclinical)
Pigmentation & Melanocortin Receptors
- Acts at melanocortin receptors including MC1R on melanocytes.
- MC1R activation is linked to melanogenesis and changes in
eumelanin production in pigmentation models. - Used to study UV-response pathways, melanin production, and
photobiology in vitro and in vivo.
CNS & Autonomic Pathways
- Melanocortin receptors (e.g., MC3R/MC4R) are expressed in central nervous
system regions regulating appetite, energy balance, and autonomic output. - Experimental work explores CNS-mediated effects on behavior,
appetite, and autonomic markers. - Interest in overlapping biology with other ?-MSH–derived peptides, including
PT-141/Bremelanotide.
Selected Research Highlights
- Pigmentation Research: Melanotan II has been used as a reference
melanocortin agonist in models of skin pigmentation, tanning response,
and UV-protection pathways. - CNS & Behavioral Models: Experimental studies examine
melanocortin signaling in appetite, mood, and autonomic regulation. - Melanocortin System Biology: Serves as a tool compound for mapping
MC1R–MC4R receptor networks and downstream intracellular signaling
(e.g., cAMP/PKA pathways).
Chemical & Handling Information
- Type: Synthetic melanocortin receptor agonist peptide
- Peptide family: ?-MSH–derived cyclic peptide analog
- Appearance: White to off-white lyophilized powder
Specifications
- Peptide: Melanotan II
- Amount: 10 mg per vial
- Form: Lyophilized powder
- Purity: ?99% (HPLC); COA per lot available
- Packaging: Sealed vials suitable for standard laboratory handling
Storage & Stability
- Store lyophilized vials in a cool, dry place, protected from light.
- Refrigeration or freezing of the lyophilized peptide is recommended for extended stability,
according to laboratory SOPs. - After reconstitution, store at 2–8 °C for short-term use.
- For long-term storage, aliquot and freeze at ?20 °C or below; avoid repeated freeze–thaw cycles.
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