Melanotan II 10 mg

Melanotan II is a synthetic cyclic heptapeptide of the melanocortin chemical class, closed by a side- chain lactam bridge between aspartic acid and lysine residues and carrying an N-terminal acetylated norleucine and a C-terminal primary amide. It is a conformationally constrained analogue built around the His-D-Phe-Arg-Trp core motif derived from alpha-melanocyte-stimulating hormone. It differs from bremelanotide only at the C-terminus, where bremelanotide carries a free acid in place of the amide.

The molecular targets are the five melanocortin receptor subtypes, MC1R through MC5R, all class A G- protein-coupled receptors. Subtype affinity is measured in recombinant membrane preparations expressing a single subtype each, by competition displacement of a labelled reference ligand under matched buffer conditions. Functional coupling is quantified in the corresponding transfected cell lines by cAMP accumulation, giving per-subtype EC50 values. The constrained cyclic scaffold is routinely used as a comparator ligand when characterising the assay system itself.

Primary literature on conformationally constrained cyclic melanocortin peptide chemistry and on melanocortin receptor subtype binding and cAMP assay methodology is indexed in PubMed, with identity and structure records in PubChem. Search results and cited literature do not establish the performance of a commercial lot or a use recommendation.