Description
GHK-Cu 100 mg — Copper Tripeptide Complex for Regenerative Research
GHK-Cu is a copper(II) complex of the endogenous tripeptide
glycyl-L-histidyl-L-lysine (GHK). It has been studied in preclinical and exploratory
clinical settings for roles in wound repair, skin regeneration, hair biology,
and extracellular-matrix (ECM) remodeling. GHK-Cu is of interest as a
signaling molecule that can influence growth factors, inflammatory mediators,
and matrix-metaloproteinase (MMP) balance in various tissue models.
What It Is
- Class: Endogenous tripeptide–copper complex
- Peptide sequence: Gly-His-Lys (GHK) chelating Cu2+
- Concept: Naturally occurring low–molecular weight peptide
found in plasma and tissues, studied as a regulator of repair and remodeling
processes when complexed with copper.
Proposed Mechanisms (Preclinical)
ECM & Tissue Remodeling
- Explored for stimulation of collagen, elastin, and glycosaminoglycan
synthesis in fibroblast and skin models. - Modulation of MMP/TIMP balance (matrix metalloproteinases and tissue
inhibitors of metalloproteinases) associated with ECM turnover. - Support of wound closure, granulation-tissue quality, and tensile strength
in animal injury models.
Inflammation, Oxidative Stress & Hair Biology
- Investigated for anti-inflammatory and antioxidant-linked
effects, including changes in cytokine and reactive-oxygen–species markers. - Preclinical and cosmetic research on hair-follicle signaling,
anagen/follicle-support markers, and scalp–skin parameters. - Model-dependent changes in angiogenesis and microcirculation in skin and
subcutaneous tissues.
Selected Research Highlights
- Skin Regeneration: GHK-Cu has been studied in creams, solutions, and
injectable formats (research/clinical) for effects on wrinkles, elasticity, and overall
skin appearance, often compared with retinoids or other actives. - Wound-Healing Models: Animal and in vitro work suggests improvements
in wound contracture, epithelialization, and ECM organization vs. controls. - Hair & Scalp: Investigations have examined changes in hair density,
shaft thickness, and scalp quality when GHK-Cu is incorporated into topical formulations. - Systemic Markers: Experimental studies have explored impacts on
oxidative-stress markers, inflammatory mediators, and gene-expression panels related
to repair and aging.
Chemical & Handling Information
- Type: Copper(II) tripeptide complex (GHK-Cu)
- Peptide length: 3 amino acids (glycyl-L-histidyl-L-lysine)
- Appearance: Blue to blue-green lyophilized powder (color may vary by lot
due to copper content and excipients)
Specifications
- Peptide: GHK-Cu
- Amount: 100 mg per vial
- Form: Lyophilized powder
- Purity: ?99% (HPLC); COA per lot available
- Packaging: Sealed vials suitable for standard laboratory handling
Storage & Stability
- Store lyophilized vials in a cool, dry place, protected from light.
- Refrigeration or freezing of the lyophilized peptide is recommended for extended stability,
according to laboratory SOPs. - After reconstitution, store at 2–8 °C for short-term use.
- For long-term storage, aliquot and freeze at ?20 °C or below; avoid
repeated freeze–thaw cycles.
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