Description
CJC-1295 (no DAC) — GHRH Analog for Research
CJC-1295 (no DAC) is a synthetic growth-hormone–releasing hormone (GHRH) analog
designed for laboratory use. The “no DAC” designation indicates that this variant does not
contain the drug-affinity complex (DAC) motif, and therefore has a shorter circulating half-life than
DAC-modified versions. In preclinical models, CJC-1295 (no DAC) is used to study pulsatile GH
secretion and downstream IGF-1–linked signaling.
What It Is
- Class: GHRH (growth hormone–releasing hormone) analog
- Sequence: 30–amino-acid peptide based on GHRH(1–29) with stabilizing substitutions
- Variant: “No DAC” — lacks the drug-affinity complex for shorter, more physiological exposure
Proposed Mechanisms (Preclinical)
GHRH Receptor Activation
- Binds to GHRH receptors on pituitary somatotroph cells.
- Engages Gs/cAMP/PKA signaling pathways linked to GH release.
- Supports pulsatile GH secretion patterns in contrast to continuous stimulation models.
Downstream Endocrine Effects
- Explored for effects on circulating GH and IGF-1 profiles in animal studies.
- Model-dependent changes in protein synthesis, nitrogen balance, and lean mass parameters.
- Frequently studied in combination protocols with separate ghrelin mimetics (GHRPs) in research settings.
Selected Research Highlights
- GH/IGF-1 Profiles: GHRH analogs such as CJC-1295 (no DAC) have been investigated
for their ability to augment endogenous GH pulses and modulate IGF-1 production in preclinical models. - Pulsatile vs. Prolonged Exposure: Shorter-acting, non-DAC variants are often used
to study the impact of physiologic, transient receptor engagement relative to long-acting depot
formulations. - Body-Composition Models: In animal studies, GHRH analogs have been examined for
effects on lean mass indices, fat mass, and metabolic markers, typically as exploratory endpoints. - Combination Research: Co-administration with separate growth hormone–releasing
peptides (GHRPs) is a common experimental design to evaluate synergistic stimulation of GH secretion.
Chemical & Handling Information
- Type: Synthetic peptide, growth hormone–releasing hormone analog (no DAC)
- Peptide length: 30 amino acids (approximate, sequence-variant dependent)
- Appearance: White to off-white lyophilized powder
Specifications
- Peptide: CJC-1295 (no DAC)
- Amount: 10 mg per vial
- Form: Lyophilized powder
- Purity: ?99% (HPLC); COA per lot available
- Packaging: Sealed vials suitable for standard laboratory handling
Storage & Stability
- Store lyophilized vials in a cool, dry place, protected from light.
- For extended stability, keep vials refrigerated or frozen as per laboratory SOPs.
- After reconstitution, store at 2–8 °C for short-term use.
- For long-term storage, aliquot and freeze at ?20 °C or below; avoid repeated freeze–thaw cycles.
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