5-Amino-1MQ 50mg

5-Amino-1MQ is a small-molecule quinolinium salt, not a peptide. The scaffold is a quinoline ring system quaternised by a methyl group at the ring nitrogen, giving a permanently cationic heteroaromatic core, with a primary amino substituent at the 5-position of the carbocyclic ring. It is a structural analogue of the methylated nicotinamide product of N-methyltransferase chemistry, and is supplied as a salt with the counterion stated on the lot documentation.

5-Amino-1MQ is characterised as an inhibitor of nicotinamide N-methyltransferase (NNMT). Inhibition is quantified in cell-free enzyme assays that follow conversion of nicotinamide and S-adenosyl-L- methionine to 1-methylnicotinamide and S-adenosyl-L-homocysteine, with product formation measured by LC-MS/MS or by a coupled fluorescence readout. IC50 and Ki are derived across a substrate concentration series to establish competition at the nicotinamide binding site. Readouts terminate at enzyme kinetic constants.

Primary literature on this molecule covers quinolinium salt synthesis and purification chemistry, structure-activity work on the methylquinolinium scaffold, and the cell-free enzymology of nicotinamide N-methyltransferase inhibition. Search results and cited literature do not establish the performance of a commercial lot or a use recommendation.