Cagrilintide 10mg

Cagrilintide is a synthetic 32-amino-acid peptide analogue of human amylin (islet amyloid polypeptide), incorporating sequence substitutions drawn from salmon calcitonin at positions associated with aggregation resistance. The backbone carries a C-terminal amide and the intramolecular disulfide bridge characteristic of the amylin family. A C20 diacid lipid chain is attached through a γ-glutamate and di-OEG linker at a lysine side chain.

The molecular targets of interest are the amylin receptor complexes AMY1, AMY2 and AMY3, each a heterodimer of the calcitonin receptor (CTR) with receptor activity-modifying protein RAMP1, RAMP2 or RAMP3, together with the calcitonin receptor itself. Engagement is quantified in vitro as radioligand or fluorescent-ligand binding affinity (Ki) against membranes from cells co-transfected with CTR and a single RAMP isoform. Functional occupancy is read out as intracellular cAMP accumulation with EC50 values calculated per receptor complex. All values described here are instrument readings from defined recombinant cell systems.

Primary literature on amylin-analogue peptide chemistry, acylation strategy and calcitonin/RAMP receptor pharmacology is indexed in PubMed and in peer-reviewed peptide-chemistry journals, with sequence and structural records catalogued in PubChem and ChEMBL. Search results and cited literature do not establish the performance of a commercial lot or a use recommendation.