Description
AOD-9604 5 mg — hGH Fragment Analog for Metabolic Research
AOD-9604 is a synthetic peptide analog based on the C-terminal fragment
(residues 176–191) of human growth hormone (hGH), with additional substitutions designed
to stabilize the sequence. In preclinical and exploratory clinical research, AOD-9604 has
been investigated for its effects on adipocyte metabolism, lipolytic signaling, and
energy-balance markers, with an emphasis on fat-mass–related endpoints rather than
classical hGH growth effects.
What It Is
- Class: hGH fragment analog (176–191–derived sequence)
- Concept: Retains regions of hGH thought to influence
lipolysis and anti-lipogenesis, while lacking domains associated with
growth-promoting and hyperglycemic actions in standard models. - Format: Research-grade synthetic peptide supplied as a lyophilized powder.
Proposed Mechanisms (Preclinical)
Adipocyte Metabolism
- Explored for stimulation of lipolysis (breakdown of stored triglycerides)
in adipocytes in vitro. - Investigated for anti-lipogenic actions (reduced lipid accumulation) in
diet-induced obesity models. - Studies suggest activity that is ?-adrenergic–independent, differentiating
it from classical catecholamine-driven lipolysis.
Systemic & Metabolic Endpoints
- Animal studies have evaluated changes in fat-mass distribution and
body-weight trajectories under high-calorie feeding. - Exploratory human datasets have examined safety, tolerability, and effects on
obesity-related measures in selected cohorts. - Ongoing research interest in glucose and lipid markers, inflammatory indices, and
overall metabolic profile modulation.
Selected Research Highlights
- Obesity Models: AOD-9604 has been tested in rodent models of diet-induced
obesity for effects on body fat, weight gain, and adipose-tissue histology. - Human Studies: Early-phase clinical work has primarily focused on safety
and tolerability, with exploratory analysis of weight-related and metabolic endpoints. - Mechanistic Distinction: Compared with full-length hGH, fragment-based
analogs such as AOD-9604 are studied for the potential to isolate fat-metabolism pathways
from broader growth and glucose effects.
Chemical & Handling Information
- Type: Synthetic peptide, hGH fragment analog
- Peptide length: Short peptide derived from hGH(176–191) with stabilizing substitutions
- Appearance: White to off-white lyophilized powder
Specifications
- Peptide: AOD-9604
- Amount: 5 mg per vial
- Form: Lyophilized powder
- Purity: ?99% (HPLC); COA per lot available
- Packaging: Sealed vials suitable for standard laboratory handling
Storage & Stability
- Store lyophilized vials in a cool, dry place, protected from light.
- For extended stability, refrigeration or freezing of the lyophilized peptide is recommended per laboratory SOPs.
- After reconstitution, store at 2–8 °C for short-term use.
- For long-term storage, aliquot and freeze at ?20 °C or below; avoid repeated freeze–thaw cycles.
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