GHK-Cu 100 mg

GHK-Cu is the copper(II) coordination complex of the tripeptide glycyl-L-histidyl-L-lysine (GHK, CAS 72957-37-0). The metal centre is held by the terminal glycyl amine nitrogen, the deprotonated glycyl- histidyl backbone amide nitrogen and the histidine imidazole nitrogen, giving the characteristic blue complex. It is supplied as the lyophilized complex rather than as the metal-free tripeptide.

GHK-Cu has no named receptor in the peer-reviewed chemical literature; its defining molecular interaction is the coordination of copper(II) itself. Complex geometry and stoichiometry are characterised in vitro by UV-visible absorbance in the d-d and charge-transfer regions, circular dichroism and EPR spectroscopy. Conditional stability constants and copper exchange with competing ligands such as albumin or histidine are determined by potentiometric titration and by spectrophotometric competition experiments in buffered systems. Measurements are reported at the level of the metal-peptide coordination equilibrium.

Primary literature on the coordination chemistry, speciation and spectroscopic characterisation of glycyl-L-histidyl-L-lysine copper(II) is indexed in PubMed and in bioinorganic and peptide chemistry journals. Search results and cited literature do not establish the performance of a commercial lot or a use recommendation.