Description
IGF-1 LR3 1 mg — Long-Arg Insulin-Like Growth Factor-1 Analog for Research
IGF-1 LR3 (Long-Arginine 3 Insulin-Like Growth Factor-1) is a modified
analog of human IGF-1 engineered to have a prolonged half-life and reduced binding
to IGF-binding proteins (IGFBPs). In preclinical research, IGF-1 LR3 is used to
study growth signaling, protein synthesis, glucose metabolism, and cellular repair
pathways in various tissues.
What It Is
- Class: Insulin-like growth factor-1 (IGF-1) analog
- Modifications: Extended N-terminus (LR3) with an arginine substitution at position 3
to reduce IGFBP binding and prolong activity in experimental systems. - Research focus: Anabolic signaling, cell growth, differentiation, and metabolism.
Proposed Mechanisms (Preclinical)
IGF-1 Receptor & Downstream Signaling
- Binds to the IGF-1 receptor (IGF-1R) on target cells.
- Activates PI3K/Akt/mTOR and MAPK/ERK pathways linked to
protein synthesis, cell growth, and survival. - Reduced IGFBP binding vs. native IGF-1 may allow for more sustained receptor engagement
in vitro and in vivo models.
Metabolic & Tissue Effects
- Explored for effects on glucose uptake, nutrient partitioning, and insulin-related pathways.
- Used in models assessing muscle hypertrophy, recovery, and tissue repair
after injury or stress. - Research interest in neuroprotective and cytoprotective signaling in selected cell types.
Selected Research Highlights
- Muscle & Anabolic Models: IGF-1 analogs such as LR3 have been examined
for their ability to enhance protein synthesis, myotube growth, and recovery markers
in skeletal-muscle systems. - Cell Growth & Differentiation: Widely used in cell culture to support
proliferation, differentiation, and survival across multiple lineages. - Metabolic Research: Experimental work includes effects on glucose
metabolism, insulin sensitivity, and cross-talk with insulin signaling pathways.
Chemical & Handling Information
- Type: Recombinant IGF-1 analog (LR3)
- Peptide length: Extended variant of human IGF-1 (83 amino acids, LR3 analog)
- Appearance: White to off-white lyophilized powder
Specifications
- Peptide: IGF-1 LR3
- Amount: 1 mg per vial
- Form: Lyophilized powder
- Purity: ?99% (HPLC); COA per lot available
- Packaging: Sealed vials suitable for standard laboratory handling
Storage & Stability
- Store lyophilized vials in a cool, dry place, protected from light.
- Refrigeration or freezing of the lyophilized peptide is recommended for extended stability,
according to laboratory SOPs. - After reconstitution, store at 2–8 °C for short-term use.
- For long-term storage, aliquot and freeze at ?20 °C or below; avoid repeated freeze–thaw cycles.
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