KPV 10mg

KPV is the tripeptide L-lysyl-L-prolyl-L-valine, corresponding to residues 11–13 at the C-terminus of α-MSH. The sequence carries a free α-amine and ε-amine on the N-terminal lysine, a central proline imposing a constrained backbone geometry, and a C-terminal valine carboxylate. It is supplied as a lyophilized solid.

The receptor of record for the parent sequence is melanocortin receptor 1 (MC1R); affinity is quantified by radioligand displacement in membrane preparations from MC1R-expressing cells. Because the tripeptide lacks the His-Phe-Arg-Trp core of the parent sequence, comparative affinity is measured side by side with full-length α-MSH in the same membrane format. Intracellular distribution is measured by fluorescent-tracer uptake and confocal imaging in cultured cells. Reported values are binding constants and uptake measurements in these defined systems.

Peer-reviewed literature covers the solid-phase synthesis and analytical characterisation of short melanocortin-derived sequences and the radioligand pharmacology of the melanocortin receptor family. Search results and cited literature do not establish the performance of a commercial lot or a use recommendation.