PT-141 / Bremelanotide 10mg Research Material

Q: What is the intended use of this material?

It is supplied for laboratory research and analytical work only and is not intended for human or veterinary use.

Q: What purity documentation accompanies the vial?

Each vial is traceable to a per-lot certificate of analysis recording the HPLC purity result, measured content, mass confirmation, testing laboratory and test date for that specific lot.

Q: How is the cyclic structure confirmed analytically?

LC-MS mass confirmation distinguishes the intact lactam-bridged cyclic peptide from the linear ring-opened species, which differ by 18 Da, and the HPLC trace resolves them as separate peaks.

PT-141 / Bremelanotide 10mg

$30.00

Research profileLab documentation

PT-141 (bremelanotide) 10mg vial listing with per-lot HPLC COA, analytical identity data, and handling guidance. Laboratory research use only, U.S. shipped.

MaterialPT-141 / Bremelanotide 10mg

Amount10mg per vial

FormLyophilized powder

Purity≥99% by HPLC · per-lot COA

StorageUnopened vial: store sealed, dry, and protected from light at controlled room temperature or refrigerated. After opening or reconstitution: keep refrigerated at 2–8 °C.

In stock · Fulfilled from Austin, TexasMost in-stock orders are usually processed within 1 business day after order review and payment approval.

CompoundBremelanotide (PT-141); Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH

CAS189691-06-3

Molecular formulaC50H68N14O10

Molecular weight1025.2 Da

Purity≥99% by HPLC · per-lot COA

Physical formLyophilized powder

Amount10mg per vial

StorageUnopened vial: store sealed, dry, and protected from light at controlled room temperature or refrigerated. After opening or reconstitution: keep refrigerated at 2–8 °C.

Available documentation

Product image & laboratory directory

Review the product image below and use the Lab Tests directory for published laboratory records.

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Product image for PT-141 / Bremelanotide 10mg — Product image

Product-specific laboratory reports, when available, are published in the Lab Tests directory. No task-matched report is currently mapped to this product page.

Bremelanotide is a synthetic cyclic heptapeptide of the melanocortin chemical class. The ring is closed by a lactam bridge between the side chains of an aspartic acid and a lysine residue, with an N-terminal acetylated norleucine outside the ring and a free C-terminal acid. It is the des-amide analogue of melanotan II, differing from that molecule at the C-terminus, and both derive structurally from the His-Phe-Arg-Trp core motif of alpha-melanocyte-stimulating hormone.

The molecular targets are the melanocortin receptors, a family of five class A G-protein-coupled receptor subtypes designated MC1R through MC5R. Subtype affinity is determined in recombinant cell membranes individually expressing each subtype, by competition displacement of a labelled reference ligand, producing a per-subtype Ki profile. Gs coupling is quantified in the matched transfected cell lines as cAMP accumulation. All reported values are properties of the specific recombinant construct, host cell line and buffer system used.

Competition binding and displacement assays across MC1R-MC5R recombinant membrane panels
cAMP accumulation and beta-arrestin recruitment assays in transfected cell lines
Subtype-selectivity profiling against matched melanocortin reference ligands
Reference standard for HPLC and LC-MS method development and system suitability
Lactam-bridge integrity and ring-opening characterisation by LC-MS
Peptide stability and solubility characterisation under defined buffer conditions

What is the intended use of this material?

What purity documentation accompanies the vial?

How is the cyclic structure confirmed analytically?

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