SS-31 (Elamipretide) 50mg

Elamipretide, also designated SS-31, is a synthetic tetrapeptide built on an alternating aromatic- cationic motif. Its sequence is D-Arg-Dmt-Lys-Phe-NH2, in which Dmt is the non-proteinogenic residue 2′,6′-dimethyltyrosine and the C-terminus is amidated. The D-arginine residue and the C-terminal amide are structural features of the Szeto-Schiller peptide series to which it belongs.

The characterised molecular partner of elamipretide is cardiolipin, an anionic diphosphatidylglycerol lipid of the inner mitochondrial membrane. Association is measured in vitro in defined liposome and isolated-membrane systems by surface plasmon resonance, isothermal titration calorimetry and fluorescence anisotropy. The alternating aromatic-cationic motif governs partitioning into anionic lipid bilayers, which is quantified as a partition coefficient under fixed buffer and lipid- composition conditions. Reported measurements stop at the peptide-lipid binding interaction.

Primary literature on the synthesis, structure-activity chemistry and cardiolipin-binding characterisation of the Szeto-Schiller aromatic-cationic tetrapeptide series is indexed in PubMed and in peptide chemistry and bioenergetics journals. Search results and cited literature do not establish the performance of a commercial lot or a use recommendation.