Description
Sermorelin 5 mg — GHRH(1–29) Analog for GH Axis Research
Sermorelin is a synthetic peptide corresponding to the
1–29 amino-acid fragment of growth hormone–releasing hormone (GHRH),
the minimal sequence required for full biological activity at the GHRH receptor.
In preclinical and clinical research, Sermorelin has been investigated for its ability
to stimulate endogenous growth hormone (GH) secretion and modulate
downstream IGF-1 and body-composition markers.
What It Is
- Class: GHRH(1–29) analog
- Peptide length: 29 amino acids
- Research focus: Pulsatile GH release, GH/IGF-1 axis dynamics,
and endocrine responses in aging, deficiency, or metabolic models.
Proposed Mechanisms (Preclinical)
GHRH Receptor Activation
- Binds to GHRH receptors on anterior pituitary somatotrophs.
- Engages cAMP/PKA signaling to promote GH synthesis and secretion.
- Supports physiologic, pulsatile GH release rather than continuous
exogenous GH exposure.
GH/IGF-1 & Body-Composition Endpoints
- Experimental work evaluates changes in GH and IGF-1 profiles over time.
- Model-dependent exploration of lean mass, fat mass, and metabolic parameters
in response to GH-axis modulation. - Commonly paired with GHRP-class secretagogues (e.g., Ipamorelin)
in research protocols to examine potential synergy.
Selected Research Highlights
- GH Deficiency & Aging Models: Sermorelin has been used to probe
age-related declines in GH secretion and to characterize GH responsiveness
in deficiency or borderline states. - Diagnostic & Functional Testing: GHRH(1–29) analogs have been
applied in stimulation tests to evaluate pituitary GH reserve in research and clinical
contexts. - Body-Composition & Metabolic Outcomes: Pilot studies have examined
markers such as lean mass, fat distribution, and metabolic indices as exploratory endpoints
of GH-axis modulation.
Chemical & Handling Information
- Type: Synthetic GHRH(1–29) peptide analog
- Peptide length: 29 amino acids
- Appearance: White to off-white lyophilized powder
Specifications
- Peptide: Sermorelin
- Amount: 5 mg per vial
- Form: Lyophilized powder
- Purity: ?99% (HPLC); COA per lot available
- Packaging: Sealed vials suitable for standard laboratory handling
Storage & Stability
- Store lyophilized vials in a cool, dry place, protected from light.
- Refrigeration or freezing of the lyophilized peptide is recommended for extended stability,
according to laboratory SOPs. - After reconstitution, store at 2–8 °C for short-term use.
- For long-term storage, aliquot and freeze at ?20 °C or below; avoid repeated freeze–thaw cycles.
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